Veiled Chameleons should be housed in spacious, well-ventilated vertically oriented enclosures. Many keepers have housed them successfully in screen-top terrariums, but enclosures with 2 or more sides screened are often recommended, because they produce much needed ventilation and because chameleons are sometimes stressed by their reflections in the glass. It is best to house hatchlings in relatively small enclosures, about the size of a 10-gallon terrarium. Juveniles up to about 6 inches (15 centimeters) in length should be housed in a 20-gallon terrarium or similar sized enclosure. The minimum size recommended for an adult female is 3 feet tall by 2 feet square, (0.9 meters tall by 0.6 meters square) and for an adult male the minimum size is 4 feet tall by 2 feet square (1.2 meters by 0.6 meters). Because of their solitary and territorial nature, it is recommended that chameleons be housed individually. Males are particularly intolerant of other males, and they should not be kept together. If multiple chameleons are housed together, their enclosure should be larger and should have plenty of visual barriers.

Loose substrates such as sand, soil, wood shavings, and bark chips should not be used in chameleon cages because they might be accidentally ingested. Many keepers prefer to leave the enclosure floor bare. Newspaper and butcher paper are commonly used substrates and can make cleaning a bit easier, but they also give insects something to hide beneath.

Their enclosures should have plenty of branches to climb on and foliage. Some keepers prefer artificial foliage, because it is easier to maintain than live plants, but because Veiled Chameleons sometimes eat plants, there is a risk of it being ingested by the chameleon. For this same reason, care must be taken when selecting live plants. Be sure to only use plants that are considered nontoxic such as hibiscus, scheffelera, and pothos. Fiscus is also commonly used with no apparent problems, but this plant secretes a sap that some believe could irritate their eyes.

Chameleons should be exposed to full spectrum UV lighting for about 13 hours a day. The ambient daytime temperature should be about 85 degrees Fahrenheit (29 degrees Celsius) with a basking spot between 95 and 100 degrees Fahrenheit (35 and 38 degrees Celsius). At night, the temperature should drop to between 70 and 75 degrees (21 and 24 degrees Celsius). These chameleons often do best at moderate humidity levels (about 50%), which are commonly maintained by setting up a drip system or with regular misting or a combination of both. This will also provide drinking water for the chameleon, as they usually will not drink from bowls, but rather drink water droplets on leaves.

Veiled Chameleons should be fed a variety of insects such as crickets, mealworms, earthworms, waxworms, flies, cockroaches, and slugs, and they can be given pinkie mice occasionally. It is recommended that insects always be dusted with a calcium supplement, and a multivitamin used about once a week will help ensure the chameleon is receiving the proper nutrition. Adults should also be offered a variety of plant matter. Dark leafy green vegetables such as collards, dandelion greens, turnip greens, and kale are very nutritious. Grape leaves and edible flowers are also good options. Some Veileds eat plant matter more readily than others, and juveniles usually eat only insects.

Chameleons are delicate animals that need to be handled with extreme care. The feet and tail can grasp objects very tightly and can easily be damaged if the chameleon is pulled away roughly. It is also important to keep in mind that falls can easily prove fatal for chameleons. Veiled Chameleons may jump out of your hands, if frightened by a sudden movement or sound or if they are not accustomed to being handled. Making sure they never have far to fall when being handled will help prevent a serious injury, if such an accident does occur. Also, be sure that all branches in the chameleon's enclosure are stable and strong enough to support the chameleon's weight.